Founded on clinical trials with proven efficacy.

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SYMBYX Research Currently Underway

Trial Location Brief of Research Scientific Partners Status Press Release
Hamilton, Canada (2023)
A clinical trial is underway to assess the effectiveness of the SYMBYX system, which consists of the PDCare laser and the SYMBYX Neuro helmet, in treating motor and non motor symptoms of Parkinson’s disease. The study has been designed as a randomized controlled trial, including a placebo group, and will involve 60 participants who will receive treatment with either the SYMBYX system or a placebo. Participants in the trial will receive exercise physiotherapy as well as light therapy. The aim of the trial is to determine whether the SYMBYX system is an effective treatment option for Parkinson’s disease symptoms.
Saltmarche Associates; Gaitway Neurophysio
Commenced Recruiting
March 31, 2022 Read Here
Adelaide, Australia (2023)
Cinical trial is examining the effectiveness of the SYMBYX system, consisting of the PDCare laser and the Neuro helmet, in treating non-motor symptoms of Parkinson’s disease. The study is designed as a randomized controlled trial, including a placebo group, and involves 36 participants who will receive either the SYMBYX system or a placebo treatment. The aim of the trial is to assess whether the SYMBYX system is a viable treatment option for non-motor symptoms associated with Parkinson’s disease.
Flinders University, Adelaide. Parkinson’s SA
Recruiting
January 6, 2021 Read Here
Brisbane, Australia (2023)
A clinical trial is being conducted to test the effectiveness of the SYMBYX laser light in reducing symptoms associated with Inflammatory Bowel Disease (IBD) in young adults. The study aims to evaluate the efficacy of the treatment and determine whether the SYMBYX laser light can be used as a potential therapeutic option for managing IBD symptoms in this population.
Mater Research Hospital, Brisbane
Recruiting
June 2, 2022 Read Here

Light Therapy Research

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A novel transcranial photobiomodulation device to address motor signs of Parkinson's disease: a parallel randomised feasibility study 2023 THE LANCET Read Here
A Randomized Placebo-Controlled Study of a Transcranial Photobiomodulation Helmet in Parkinson’s Disease: Post-Hoc Analysis of Motor Outcomes 2023 Journal of Clinical Medicne Read Here
Modifiable Variables in Parkinsonism (MVP) Study. ongoing Read Here
Therapies for Parkinson's disease and the gut microbiome: evidence for bidirectional connection. 2023 Frontiers in Aging Neuroscience Read Here
The gut-brain vascular axis in neuroinflammation. 2023 Seminars in Immunology Read Here
Photophysical Mechanisms of Photobiomodulation Therapy as Precision Medicine. 2023 Biomedicines Read Here
Microbiome Changes in Humans with Parkinson’s Disease after Photobiomodulation Therapy: A Retrospective Study. 2022 Journal of Personalised Medicine Read Here
The Molecular Mechanisms of Action of Photobiomodulation Against Neurodegenerative Diseases: A Systematic Review. 2022 Cellular and Molecular Neurobiology Read Here
Photobiomodulation, as additional treatment to traditional dressing of hard-to-heal venous leg ulcers, in frail elderly with municipality home healthcare. 2022 PloS One Read Here
Remote Photobiomodulation Treatment for the Clinical Signs of Parkinson's Disease: A Case Series Conducted During COVID-19. 2022 Photobiomodulation, Photomedicine, and Laser Surgery Read Here
Transcranial photobiomodulation in the management of brain disorders. 2021 Journal of Photochemistry Read Here
Improvements in clinical signs of Parkinson’s disease using photobiomodulation: a prospective proof-of-concept study. 2021 BMC Neurology Read Here
Sensory-Evoked 40-Hz Gamma Oscillation Improves Sleep and Daily Living Activities in Alzheimer’s Disease Patients. 2021 Frontiers in Systems Neuroscience Read Here
Mitochondrial Dysfunction and Parkinson’s Disease-Near-Infrared Photobiomodulation as a Potential Therapeutic Strategy. 2020 Frontiers in Aging Neuroscience Read Here
Exploring the Effects of Near Infrared Light on Resting and Evoked Brain Activity in Humans Using Magnetic Resonance Imaging. 2019 Neuroscience Read Here
Brain-First versus Gut-First Parkinson's Disease: A Hypothesis. 2019 Journal of Parkinson's disease Read Here
Mechanisms and Applications of the Anti-inflammatory effects of Photobiomodulation. 2017 AIMS Biophysics Journal Read Here
The gut-brain axis: is intestinal inflammation a silent driver of Parkinson’s disease pathogenesis? 2017 NPJ Parkinson's Disease Read Here
Photobiomodulation: Implications for Anesthesia and Pain Relief. 2016 Mary Ann Libert Read Here
The Onset of Non Motor Symptoms in Parkinson’s disease. 2015 Movement Disorders Read Here
Low-level laser therapy in meniscal pathology: a double-blinded placebo-controlled trial. 2013 Lasers in Medical Science Read Here
Efficacy of low level laser therapy associated with exercises in knee osteoarthritis: a randomized double-blind study. 2012 Clinical Rehabilitation Read Here
Short-term efficacy of low-level laser therapy in patients with knee osteoarthritis: a randomized placebo-controlled, double-blind clinical trial. 2011 Revista Brasileira de Ortopedia Read Here
The application of low-level laser therapy for the symptomatic care of late stage Parkinson's disease: A non-controlled, non-randomized study. 2010 Lasers in surgery and medicine Read Here
Clinical progression in Parkinson's disease and the neurobiology of axons. 2010 Annals of Neurology Read Here
A Randomized Placebo-Controlled Study of a Transcranial Photobiomodulation Helmet in Parkinson’s Disease: Post-Hoc Analysis of Motor Outcomes. 2006 Journal of Clinical Medicine Read Here
A holistic perspective on how photobiomodulation may influence fatigue, pain, and depression in inflammatory bowel disease: Beyond moelcular mechanisms. 2006 Biomedicines Read Here
A randomised, placebo controlled trial of low level laser therapy for activated Achilles tendinitis with microdialysis measurement of peritendinous prostaglandin E2 concentrations. 2006 British Journal of Sports Medicine Read Here
Low level las therapy (LLT) of tendonitis and myofascial pains a randomized, double-blind controlled study. 2004 Laser Therapy Read Here
Movement Disorders Movement Disorders Gaps & Controversies Unmet Needs of Women Living with Parkinson's Disease: Gaps and Controversies 2022 Movement Disorders Read Here

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