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SYMBYX Research Highlights

Improvements in clinical signs of Parkinson’s disease using photobiomodulation: a prospective proof-of-concept study
A Randomized Placebo-Controlled Study of a Transcranial Photobiomodulation Helmet in Parkinson’s Disease: Post-Hoc Analysis of Motor Outcomes
Improvements in clinical signs and symptoms of Parkinson’s disease using photobiomodulation: a five-year follow-up
Improvements in clinical signs of Parkinson’s disease using photobiomodulation: a prospective proof-of-concept study

BMC Neurology, 2 July 2021

PBM was shown to be a safe and potentially effective treatment for a range of clinical signs and symptoms of PD. Improvements were maintained for as long as treatment continued, for up to one year in a neurodegenerative disease where decline is typically expected. Home treatment of PD by the person themselves or with the help of a carer might be an effective therapy option. The results of this study indicate that a large RCT is warranted.

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A Randomized Placebo-Controlled Study of a Transcranial Photobiomodulation Helmet in Parkinson’s Disease: Post-Hoc Analysis of Motor Outcomes

Journal of Clinical Medicine, April 13, 2023

This remotely run study is the first triple blind RCT assessing efficacy and safety of a novel transcranial PBM device for PD. It was found that tPBM was safe, well tolerated and improved specific motor symptoms for a majority of the sub-scores of the treatment cohort. Current treatments for PD provide limited long-term results, highlighting the need to examine new and less-researched therapies. The use of tPBM to treat symptoms of PD reflects an emerging application of light-based technologies to expand treatment options. The response of some participants to tPBM treatment in this study suggests that further research with a larger trial is needed to build an understanding of the application of tPBM to treat the symptoms of PD. Finally, the characteristics of PD patients who might respond positively to tPBM therapy requires further exploration. The results of this study are encouraging and suggest that tPBM can meaningfully improve individual motor signs of PD and be used as a safe and non-pharmaceutical adjunct treatment for the management of symptoms of PD.

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Improvements in clinical signs and symptoms of Parkinson’s disease using photobiomodulation: a five-year follow-up

BMC Neurology, October 9, 2024.

Improvements in clinical signs and symptoms of Parkinson’s disease using photobiomodulation: a five-year follow-up.

This study provides a signal that photobiomodulation therapy might safely reduce important clinical motor signs and non-motor symptoms in some Parkinson’s disease patients, with improvements maintained over several years. Home-based photobiomodulation therapy has the potential to complement standard therapies to manage symptoms and potentially delay Parkinson’s symptom progression.

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Published Research

Trial Location Research Paper Publication links
Sydney, Australia
Improvements in clinical signs and symptoms of Parkinson’s disease using photobiomodulation: a five-year follow-up
BMC Neurology, October 9, 2024 Read Here
Sydney, Australia
A novel transcranial photobiomodulation device to address motor signs of Parkinson's disease: a parallel randomised feasibility study.
THE LANCET eClinicalMedicine, 1 December 2023 Read Here
Sydney, Australia
A Randomized Placebo-Controlled Study of a Transcranial Photobiomodulation Helmet in Parkinson’s Disease: Post-Hoc Analysis of Motor Outcomes. First 12 weeks results.
Journal of Clinical Medicine, 13 April 2023 Read Here
Adelaide, Australia
Microbiome Changes in Humans with Parkinson’s Disease after Photobiomodulation Therapy: A Retrospective Study.
Journal of Personalised Medicine, January 5, 2022 Read Here
Sydney, Australia
Remote Photobiomodulation Treatment for the Clinical Signs of Parkinson’s Disease: A Case Series Conducted During COVID-19.
PBM, Photomedicine, and Laser Surgery, December 16, 2021 Read Here
Sydney, Australia
Photophysical Mechanisms of Photobiomodulation Therapy as Precision Medicine.
Biomedicines, Jan 17, 2023 Read Here
Brisbane, Australia
A Holistic Perspective on How Photobiomodulation May Influence Fatigue, Pain, and Depression in Inflammatory Bowel Disease: Beyond Molecular Mechanisms.
Biomedicines, May 22, 2023 Read Here
Adelaide, Australia
Improvements in clinical signs of Parkinson’s disease using photobiomodulation: a prospective proof-of-concept study.
BMC Neurology, July 2, 2021 Read Here

Research Currently Underway

Trial Location Brief of Research Scientific Partners Status Press Release
The University of Leeds
This pioneering study, led by Professors Lijing Ke (Plant Biochemistry and Nutrition) and Kieran Tuohy (Energy Metabolism and Microbiome) from the University of Leeds, will explore the influence of light therapy on human cells and systems. It is believed that light therapy reduces oxidative stress and increases energy metabolism at a cellular level. These changes are then transmitted to surrounding cells, triggering sequential bioelectrical and metabolic changes. The study will employ co-culture cell models alongside an in vitro model of the human colonic microbiota.
The University of Leeds
Commencing shortly
March 4, 2025 Read Here
Hamilton, Canada (2023)
A clinical trial is underway to assess the effectiveness of the SYMBYX system, which consists of the PDCare laser and the SYMBYX Neuro helmet, in treating motor and non motor symptoms of Parkinson’s disease. The study has been designed as a randomized controlled trial, including a placebo group, and will involve 60 participants who will receive treatment with either the SYMBYX system or a placebo. Participants in the trial will receive exercise physiotherapy as well as light therapy. The aim of the trial is to determine whether the SYMBYX system is an effective treatment option for Parkinson’s disease symptoms.
Saltmarche Associates; Gaitway Neurophysio
Study is almost complete
March 31, 2022 Read Here
Adelaide, Australia (2023)
Cinical trial is examining the effectiveness of the SYMBYX system, consisting of the PDCare laser and the Neuro helmet, in treating non-motor symptoms of Parkinson’s disease. The study is designed as a randomized controlled trial, including a placebo group, and involves 36 participants who will receive either the SYMBYX system or a placebo treatment. The aim of the trial is to assess whether the SYMBYX system is a viable treatment option for non-motor symptoms associated with Parkinson’s disease.
Flinders University, Adelaide. Parkinson’s SA
Study is almost complete
January 6, 2021 Read Here
Brisbane, Australia (2023)
A clinical trial is being conducted to test the effectiveness of the SYMBYX laser light in reducing symptoms associated with Inflammatory Bowel Disease (IBD) in young adults. The study aims to evaluate the efficacy of the treatment and determine whether the SYMBYX laser light can be used as a potential therapeutic option for managing IBD symptoms in this population.
Mater Research Hospital, Brisbane
Study is underway
June 2, 2022 Read Here

Light Therapy Research

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A novel transcranial photobiomodulation device to address motor signs of Parkinson's disease: a parallel randomised feasibility study 2023 THE LANCET Read Here
A Randomized Placebo-Controlled Study of a Transcranial Photobiomodulation Helmet in Parkinson’s Disease: Post-Hoc Analysis of Motor Outcomes 2023 Journal of Clinical Medicne Read Here
Modifiable Variables in Parkinsonism (MVP) Study. ongoing Read Here
Therapies for Parkinson's disease and the gut microbiome: evidence for bidirectional connection. 2023 Frontiers in Aging Neuroscience Read Here
The gut-brain vascular axis in neuroinflammation. 2023 Seminars in Immunology Read Here
Photophysical Mechanisms of Photobiomodulation Therapy as Precision Medicine. 2023 Biomedicines Read Here
Microbiome Changes in Humans with Parkinson’s Disease after Photobiomodulation Therapy: A Retrospective Study. 2022 Journal of Personalised Medicine Read Here
The Molecular Mechanisms of Action of Photobiomodulation Against Neurodegenerative Diseases: A Systematic Review. 2022 Cellular and Molecular Neurobiology Read Here
Photobiomodulation, as additional treatment to traditional dressing of hard-to-heal venous leg ulcers, in frail elderly with municipality home healthcare. 2022 PloS One Read Here
Remote Photobiomodulation Treatment for the Clinical Signs of Parkinson's Disease: A Case Series Conducted During COVID-19. 2022 Photobiomodulation, Photomedicine, and Laser Surgery Read Here
Transcranial photobiomodulation in the management of brain disorders. 2021 Journal of Photochemistry Read Here
Improvements in clinical signs of Parkinson’s disease using photobiomodulation: a prospective proof-of-concept study. 2021 BMC Neurology Read Here
Sensory-Evoked 40-Hz Gamma Oscillation Improves Sleep and Daily Living Activities in Alzheimer’s Disease Patients. 2021 Frontiers in Systems Neuroscience Read Here
Mitochondrial Dysfunction and Parkinson’s Disease-Near-Infrared Photobiomodulation as a Potential Therapeutic Strategy. 2020 Frontiers in Aging Neuroscience Read Here
Exploring the Effects of Near Infrared Light on Resting and Evoked Brain Activity in Humans Using Magnetic Resonance Imaging. 2019 Neuroscience Read Here
Brain-First versus Gut-First Parkinson's Disease: A Hypothesis. 2019 Journal of Parkinson's disease Read Here
Mechanisms and Applications of the Anti-inflammatory effects of Photobiomodulation. 2017 AIMS Biophysics Journal Read Here
The gut-brain axis: is intestinal inflammation a silent driver of Parkinson’s disease pathogenesis? 2017 NPJ Parkinson's Disease Read Here
Photobiomodulation: Implications for Anesthesia and Pain Relief. 2016 Mary Ann Libert Read Here
The Onset of Non Motor Symptoms in Parkinson’s disease. 2015 Movement Disorders Read Here
Low-level laser therapy in meniscal pathology: a double-blinded placebo-controlled trial. 2013 Lasers in Medical Science Read Here
Efficacy of low level laser therapy associated with exercises in knee osteoarthritis: a randomized double-blind study. 2012 Clinical Rehabilitation Read Here
Short-term efficacy of low-level laser therapy in patients with knee osteoarthritis: a randomized placebo-controlled, double-blind clinical trial. 2011 Revista Brasileira de Ortopedia Read Here
The application of low-level laser therapy for the symptomatic care of late stage Parkinson's disease: A non-controlled, non-randomized study. 2010 Lasers in surgery and medicine Read Here
Clinical progression in Parkinson's disease and the neurobiology of axons. 2010 Annals of Neurology Read Here
A Randomized Placebo-Controlled Study of a Transcranial Photobiomodulation Helmet in Parkinson’s Disease: Post-Hoc Analysis of Motor Outcomes. 2006 Journal of Clinical Medicine Read Here
A holistic perspective on how photobiomodulation may influence fatigue, pain, and depression in inflammatory bowel disease: Beyond moelcular mechanisms. 2006 Biomedicines Read Here
A randomised, placebo controlled trial of low level laser therapy for activated Achilles tendinitis with microdialysis measurement of peritendinous prostaglandin E2 concentrations. 2006 British Journal of Sports Medicine Read Here
Low level las therapy (LLT) of tendonitis and myofascial pains a randomized, double-blind controlled study. 2004 Laser Therapy Read Here
Movement Disorders Movement Disorders Gaps & Controversies Unmet Needs of Women Living with Parkinson's Disease: Gaps and Controversies 2022 Movement Disorders Read Here
Protocol for a Single-Arm Feasibility Study of Photobiomodulation for Fatigue, Depression, and Pain in Inflammatory Bowel Disease. 2023 Biomedicines Read Here
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